History of Immunoglobulin molecules
Snapshots in the history of Immunoglobulin molecules
Tiseluis and Kabat in 1939 showed that antibodies belong to the γ-globulin fraction of serum proteins
Porter digested γ-globulins with papain, a proteolytic
enzyme, and recovered 3 fractions: Fractions I and II of molecular weights between 50 and 55KDa retained the antigen binding capacity, whereas fraction III, of 80 KDa was crystalizable, and have a higher carbohydrate content (Porter RR, Biochem J. 73:119-127, 1959
Variable and Constant Regions
Edelman and Porter shared the Nobel Prize in Medicine in 1972 "for their discoveries concerning the chemical structure of antibodies"
(Gerald M. Edelman - Facts
. Nobel Media AB 2014.
Rodney R. Porter - Facts
Nobel Media AB 2014.)
History kindly supplied by Dr Luis Garcia – Immunopaedia Steering Committee