Koshland and coworkers demonstrated that the monomers of the polymeric IgM and IgA are linked by the J chain in a clasp way (Halpern MS and Koshland ME. Nature 228:1276-1278, 1970; Chapuis RM, Koshland ME, Proc Nat Acad Sci 71:657-661, 1974)

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University