Heavy and Light chains

Edelman and Poulik reported that rabbit 7S γ-globulins and human myeloma proteins reduced in strong urea solutions and alkylated, separated into heavy (H) and light (L) chains bound by disulfide bonds (Edelman GM and Poulik MD, J Exp Med. 113:861-884, 1961)

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University