Immunopaedia Ambassadors – Asia
Our Ambassadors from across the Asian continent.
What is your current position?
Post-Doctoral Fellow “INSPIRE Faculty” supported by Department of Science and Technology, Govt of India
Which institute and country do you work in?
Department of Immunology, Advanced Centre for Treatment Research and Education in Cancer (ACTREC)- Tata Memorial Centre, Kharghar, Navi Mumbai, India
What is your home country?
What are your research interests?
Gamma delta T cells, T cell metabolism and Cancer
Tell us about yourself and your research interests:
I completed my PhD in 2016 under the mentorship of Prof S.V. Chiplunkar from ACTREC-Tata Memorial Centre, Navi Mumbai. The research work focused on understanding the immune dysfunctions in pathogenesis of gallbladder cancer patients in India. Highlight of the study was to show that the IL17 secreting γδ-T lymphocytes (Tγδ17) induce angiogenesis and are associated with poor survival of Gallbladder cancer patients. This work received “Dr. G P Talwar young scientist award” from Indian Immunology Society. I then commenced a post-doctoral fellowship to investigate the role of exhaustion of T lymphocytes infiltrating the tumor environment of colon cancer patients, a project headed by Dr. S.V. Chiplunkar, in collaboration with ‘Bristol Meyer Squibb’, Bangalore. Recently I received an “INSPIRE Faculty award” to work at ACTREC-Tata Memorial Centre, Navi Mumbai. This is a competitive research grant given by Department of Science and Technology, Govt. of India to young investigators to pursue independent research. This grant was awarded for a project ‘Understanding the metabolic pathways regulating the functions of γδ-T cells in cancer’ which was selected after a stringent review process.
I am keen to investigate the metabolic regulation of T cells in inflammatory environment. ‘How antigenic stimulation rewires the metabolic need of gamma delta T cells and vice versa in tumor environment’ and ‘does the alterations in the metabolic preferences contribute to T cell exhaustion in tumor environment’ are the questions I am presently perusing. I am actively involved in teaching basic immunology to undergraduate students and I participate in the Immunology hands-on training workshops organised by ‘Mumbai Immunology Group’.
What are your online profiles?
Researchgate: Rushikesh Patil
Inflammation, T cells, Metabolism, immune exhaustion