Variable and Constant Regions

Edelman and coworkers reported the first complete sequence of a γG immunoglobulin molecule and demonstrated the existence of variable (V) and constant (C) regions in the H and L chains (Edelman GM et al., Proc Nat Acad Sci USA 63:78-85, 1969)

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University