Monoclonal antibodies

Kohler and Milstein (Nature 256: 495-497, 1975) reported that the fusion of a myeloma cell with a spleen specific antibody-producing cell results in a hybridoma that produces monoclonal antibodies against the specific antigen. Continuous culture of cloned hybrid cells allows the production of large amounts of monoclonal antibodies against the desired antigen.

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University