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How effective is Dexamethasone for the treatment of patients with COVID-19?

25th June

Dexamethasone is a corticosteroid that was put into clinical trial to identify whether it could modulate immune-mediated lung injury and reduce progression to respiratory failure and death in COVID-19 patients. In a pre-peer reviewed paper, preliminary results of the RECOVERY trial was reported. This was a randomized trial comparing a range of possible treatments with usual care…

Vaccine-associated enhanced respiratory disease in hamsters vaccinated against COVID-19

26 September 2022

In this study, Ebenig and colleagues were able to come up with a detailed description of what they believe to be the immune-cell mediated mechanisms responsible for inducing Vaccine-associated enhanced respiratory disease (VAERD)…

Is blocking inflammatory cell movement using chemokine receptor antagonists the way to go?

31st July

Corticosteroid treatment for severe COVID-19 could be regarded as a “heavy approach” to relieving the devastating effects of acute respiratory distress syndrome, and would potentially inhibit the signalling pathways leading to robust T and B cell immunity. Perhaps a more selective approach could be used to target the now known inflammatory overreaction leading to severe disease…

IUIS Webinar: COVID-19 in South Africa

3rd July

Since the first case of COVID-19 on 5 March 2020 in South Africa, the epidemic grew exponentially with a doubling time of 2 days for the first 3 weeks until the effects of state-initiated interventions impacted reducing the doubling time to 15 days. The National response, which comprises 8 stages aims to flatten the curve. Stage 6 of the response on clinical care has provided new insights on the immune response, the role of the cytokine storm & the impact of dexamethasone…

Case of eye injury and decreased vision

A 12 year old boy is brought into the paediatric casualty by his parents approximately 18 hours after sustaining a penetrating knife injury to his left eye. The child was here he was attacked by a fellow learner who stabbed him in his left eye. He sustained no other injuries as his attacker ran away after the incident.

A case of a 3 month old infant with bloody urine and stools

A three month old male infant presents to the emergency department with a one day history of haematochezia and haematuria, accompanied by a diffuse rash and shortness of breath. A three month old male infant was brought into the emergency department..

Case of enlarged hard tongue

A 59 year old male presents to the medical out patient department with a one month history of progressively increasing fatigue and backache.For the last month the patient has been feeling exhausted for no apparent reason…

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University