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25th June

Dexamethasone is a corticosteroid that was put into clinical trial to identify whether it could modulate immune-mediated lung injury and reduce progression to respiratory failure and death in COVID-19 patients. In a pre-peer reviewed paper, preliminary results of the RECOVERY trial was reported. This was a randomized trial comparing a range of possible treatments with usual care…

26 September 2022

In this study, Ebenig and colleagues were able to come up with a detailed description of what they believe to be the immune-cell mediated mechanisms responsible for inducing Vaccine-associated enhanced respiratory disease (VAERD)…

31st July

Corticosteroid treatment for severe COVID-19 could be regarded as a “heavy approach” to relieving the devastating effects of acute respiratory distress syndrome, and would potentially inhibit the signalling pathways leading to robust T and B cell immunity. Perhaps a more selective approach could be used to target the now known inflammatory overreaction leading to severe disease…

3rd July

Since the first case of COVID-19 on 5 March 2020 in South Africa, the epidemic grew exponentially with a doubling time of 2 days for the first 3 weeks until the effects of state-initiated interventions impacted reducing the doubling time to 15 days. The National response, which comprises 8 stages aims to flatten the curve. Stage 6 of the response on clinical care has provided new insights on the immune response, the role of the cytokine storm & the impact of dexamethasone…

A 12 year old boy is brought into the paediatric casualty by his parents approximately 18 hours after sustaining a penetrating knife injury to his left eye. The child was here he was attacked by a fellow learner who stabbed him in his left eye. He sustained no other injuries as his attacker ran away after the incident.

A three month old male infant presents to the emergency department with a one day history of haematochezia and haematuria, accompanied by a diffuse rash and shortness of breath. A three month old male infant was brought into the emergency department..

A 59 year old male presents to the medical out patient department with a one month history of progressively increasing fatigue and backache.For the last month the patient has been feeling exhausted for no apparent reason…