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27th February

Researchers are currently exploring the potential use of IL-27 as an immunotherapeutic agent. An example of this, is the experimental administration…

The host, via its immune system, has the capacity to recognize materials as foreign to itself and to neutralize, eliminate, or metabolize them with or without injury to its own tissue(s). Some of these foreign materials can be referred to as antigens and could be entire micro-organisms like bacteria, fragments of them or substances produced Read More

Mononuclear Phagocytes Produce Key Inflammatory Cytokines and Chemokines Mononuclear phagocytes (monocytes and macrophages) are essential for the development of inflammation and together with neutrophils are the phagocytic cells involved in the clearance of inert particles and microbial agents. Monocytes are bone marrow-derived cells and are continuously released into the blood. When these cells are recruited Read More

The host, via its immune system, has the capacity to recognize materials as foreign to itself and to neutralize, eliminate, or metabolize them with or without injury to its own tissue(s). This ability to differentiate ‘self’ from ‘nonself’ constitutes the basic hallmark of the immune response and the basis for an understanding of clinical immunology Read More

Inborn errors of immunity and susceptibility to fungi Inborn errors of immunity (IEIs) are rare genetic defects affecting immune defense and homeostasis. Defects of T-cell development and differentiation, phagocytic functions, and pathways involved in the innate recognition of pathogens and downstream signaling are associated with an increased risk of fungal infections. The spectrum of fungal Read More

Mononuclear Phagocytes Produce Key Inflammatory Cytokines and Chemokines Mononuclear phagocytes (monocytes and macrophages) are essential for the development of inflammation and together with neutrophils are the phagocytic cells involved in the clearance of inert particles and microbial agents. Monocytes are bone marrow-derived cells and are continuously released into the blood. When these cells are recruited Read More

The host, via its immune system, has the capacity to recognize materials as foreign to itself and to neutralize, eliminate, or metabolize them with or without injury to its own tissue(s). This ability to differentiate ‘self’ from ‘nonself’ constitutes the basic hallmark of the immune response and the basis for an understanding of clinical immunology Read More

Leishmania introduction   Human leishmaniasis The leishmaniases are a group of neglected tropical diseases (NTDs), caused by protozoan Leishmania parasites. There is an estimated 350 million people in 98 countries who are at risk of leishmaniasis1. In 2013, the disease burden was estimated to be around 4 million disability-adjusted life years (DALYs)1, causing an estimated Read More

9th October, 2017

Oral tolerance is important in ensuring that the body does not mount an immune response against everyday foods we ingest. CD4+CD8αα+ double-positive intraepithelial lymphocytes (DP IELs)…

The host, via its immune system, has the capacity to recognize materials as foreign to itself and to neutralize, eliminate, or metabolize them with or without injury to its own tissue(s). Some of these foreign materials can be referred to as antigens and could be entire micro-organisms like bacteria, fragments of them or substances produced Read More