IUIS Webinar: Seeking correlates of COVID-19 protection and pathology


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Professor Adrian Hayday shares an overview of a completed deep immunophenotyping of 100 COVID-19 patients and controls (figure below), in the 13th IUIS webinar.

Highlights of the webinar include

  • Discovery of an immune cell signature based on cell phenotypes that distinguished COVID-19 treated patients from SARS-CoV-2 seronegative and seropositive controls. However, this signature did not correlate with SARS-CoV-2 viral burden.
  • As observed by others, Prof. Hayday also detected higher levels of in SARS-CoV-2 specific-antibodies, inflammatory (IL-6, IL-8) & anti-inflammatory (IL-10) cytokines, and activated T cells in COVID-19 patients compared to controls. They also detected higher levels of IP-10 (CXCL10) in COVID-19 patients compared to controls and patients with other lower respiratory tract infections.
  • Description an overt T cytopenia (decrease in Th1 & Th17 cells but not Tregs nor Th2 phenotypes), T cell activation (CD38+HLA-DR+) and exhaustion (PD-1+Tim-3+) in severe COVID-19 patients compared to controls.
  • Prof Hayday concluded his talk suggesting that some of these features e.g IP-10 could have prognostic value. As well as highlighting that COVID-19 disease pathology blends pathologies observed in other diseases e.g. acute respiratory distress, vasculopathy, as well as immune responses kinetics observed in other diseases such as sepsis, among other pathologies.

 

 

 
 
 
 
 
 
International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University