Disclaimer: This is a summary of an article that is in a preprint and has not been peer reviewed.
In a pre-peer reviewed bioRxiv manuscript, authors show that the adenovirus-vectored vaccine ChAdOx1 nCoV-19, encoding the spike protein of SARS-CoV-2, is immunogenic in mice, showing a robust humoral and cell-mediated response. This was recapitulated with a single immunization of ChAdOx1 nCoV-19 in rhesus macaques, inducing both humoral and cellular immune response. There was significantly reduced viral load in bronchoalveolar lavage fluid and respiratory tract tissue of vaccinated animals challenged with SARS-CoV-2 compared with control animals, and no pneumonia was observed in the vaccinated monkeys. Importantly, there was no evidence of immune-enhanced disease following viral challenge in vaccinated animals. The authors state that: “Safety, immunogenicity and efficacy against symptomatic PCR-positive COVID-19 disease will now be assessed in randomised controlled human clinical trials.”
Journal Article: van Doremalen et al., ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques. BioRxiv
Article by Clive Gray