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Epigenetics Research in Systems Immunology

Epigenetics Research in Systems Immunology: Concepts, Technologies and Future Concept of the Systems Immunology The conventional approach in immunology research has been ‘hypotheses’ driven, in which the Immunologist performs experiments, generates a set of observations and then develops a ‘mechanistic’ understanding at the end of the study. In contrast to this conventional paradigm, systems biology Read More

Leaky gut in COVID-19 and its impact on Neutrophil Extracellular Trap formation

04 May 2022

Saithong, et al., have hypothesized now that severe COVID-19 causes leaky gut and gut translocation of pathogenic cell wall components enhancing the formation of NETs and sepsis severity…

Keep up while the storm is raging

Norberto, a 23-year old white male in his third relapse of a B cell acute lymphoblastic leukemia (B-ALL) has been treated with an infusion of autologous CD19 Chimeric Antigen Receptor (CAR) T cells (CAR-T cells). Ten days later, he felt severe discomfort in the middle of the night…

Student Presentations – Week 1

Immuno-Algeria Student Presentations   Student Presentations – Week 1 Razika Zeghi-Bouteldja – Proteomic characterization of antigens involved in allergic reaction during cystic echiococcosis Sadjia Lahiani – Identification of immunodominant epitope residues of Der p 5 Allergen from Dermatophagoides pteronyssinus by alanine scanning strategy Mohamed Anis Boussahel – Agreement between Skin prick tests and specific IgE Read More

Immuno-Algeria Programme

Download the Programme – Immuno-Algeria Programme.xlsx  

Tumour Microenvironment

Tumours are organ-like structures composed of different cell types whose interactions are required to promote their maintenance, growth and metastasis. Increasing evidence indicates that the tumour microenvironment (TME) can dictate aberrant cellular function and play a critical role in the subsequent development of more advanced and refractory malignancies. TME is constituted of cancer-associated fibroblast (CAFs), Read More

Inflammation and autoinflammation

What Is Inflammation? Inflammation (Latin, inflammatio, to set on fire) is the complex biological response of vascular tissues to injury or harmful stimuli, such as those caused by pathogens, damaged cells, or irritants. In general, the following events occur during an inflammatory response: Vascular changes: blood flow increases and fluid and plasma proteins leak into Read More

Fireworks of autoimmunity from birth

A five-month-old male infant was brought into the emergency department by parents with hypotonicity (reduced muscular tone) and drowsiness that began the evening before. The infant presented with refractory atopic dermatitis and recent weight loss.

Inflammation and autoinflammation

What Is Inflammation? Inflammation (Latin, inflammatio, to set on fire) is the complex biological response of vascular tissues to injury or harmful stimuli, such as those caused by pathogens, damaged cells, or irritants. In general, the following events occur during an inflammatory response: (1) vascular changes: blood flow increases and fluid and plasma proteins leak Read More

I have spots and my skin burns

Peter, a 60 year-old Caucasian policeman, complains of a painful burning sensation in his lower extremities lasting for several months. Lower limbs petechiae (small purple/red hemorrhagic spots) appeared one week ago.

 
 
 
 
 
 
International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University