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15 September 2023

In a new study, researchers described the pivotal role of the CCR5 receptor in the development of vascular dementia…

Mononuclear Phagocytes Produce Key Inflammatory Cytokines and Chemokines Mononuclear phagocytes (monocytes and macrophages) are essential for the development of inflammation and together with neutrophils are the phagocytic cells involved in the clearance of inert particles and microbial agents. Monocytes are bone marrow-derived cells and are continuously released into the blood. When these cells are recruited Read More

Mononuclear Phagocytes Produce Key Inflammatory Cytokines and Chemokines Mononuclear phagocytes (monocytes and macrophages) are essential for the development of inflammation and together with neutrophils are the phagocytic cells involved in the clearance of inert particles and microbial agents. Monocytes are bone marrow-derived cells and are continuously released into the blood. When these cells are recruited Read More

The host, via its immune system, has the capacity to recognize materials as foreign to itself and to neutralize, eliminate, or metabolize them with or without injury to its own tissue(s). Some of these foreign materials can be referred to as antigens and could be entire micro-organisms like bacteria, fragments of them or substances produced Read More

Mononuclear Phagocytes Produce Key Inflammatory Cytokines and Chemokines Mononuclear phagocytes (monocytes and macrophages) are essential for the development of inflammation and together with neutrophils are the phagocytic cells involved in the clearance of inert particles and microbial agents. Monocytes are bone marrow-derived cells and are continuously released into the blood. When these cells are recruited Read More

The host, via its immune system, has the capacity to recognize materials as foreign to itself and to neutralize, eliminate, or metabolize them with or without injury to its own tissue(s). This ability to differentiate ‘self’ from ‘nonself’ constitutes the basic hallmark of the immune response and the basis for an understanding of clinical immunology Read More

16 July 2021

HLA-DR is a molecule typically expressed by antigen-presenting cells and is associated with antigen presentation. Interestingly HLA-DR is also expressed on T cells and has been associated with T cell activation. However, why and how activated T cells express HLA-DR is not fully understood.

Helminths are very effective in infecting human hosts leading to chronic infections. Therefore, these organisms can also be viewed as very effective xenotransplants of their respective host. Most helminths do not extensively replicate within the host, but persist life-long and rather produce eggs or larvae to spread by infection of new hosts. To circumvent expulsion Read More

Effector and memory CD8 T cell differentiation CD8+ T cells are key players of adaptive immune response in eradicating viruses and tumour cells. Differentiated effector CD8+ T cells express high levels of transcription factors (T-bet) which leads to the expression of perforin, granzyme-B and IFN-γ. In addition, transcription factor EOMES redundantly cooperates with T-bet.1,2,3,4 I Read More

Mononuclear Phagocytes Produce Key Inflammatory Cytokines and Chemokines Mononuclear phagocytes (monocytes and macrophages) are essential for the development of inflammation and together with neutrophils are the phagocytic cells involved in the clearance of inert particles and microbial agents. Monocytes are bone marrow-derived cells and are continuously released into the blood. When these cells are recruited Read More