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13 March 2024

Researchers have discovered how sleep enhances the ability of T cells, crucial to the immune system, to travel to lymph nodes…

Background Tolerance is induced and maintained both centrally and peripherally, each with a non-redundant function in maintaining receptor diversity while curtailing self-reactivity It was observed more than 50 years ago that non-identical twin calves sharing a placenta do not react to each other’s erythrocytes, and it was hypothesised that in utero exposure rendered them tolerant Read More

Metabolism of Dendritic Cells Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) of the immune system and constitute a bridge between innate and adaptive immunity. DCs comprise a highly heterogeneous cell population able to receive and interpret signals either from invading pathogens or dying cells, and to respond to them through the Read More

Helminths are very effective in infecting human hosts leading to chronic infections. Therefore, these organisms can also be viewed as very effective xenotransplants of their respective host. Most helminths do not extensively replicate within the host, but persist life-long and rather produce eggs or larvae to spread by infection of new hosts. To circumvent expulsion Read More

Dendritic cells characteristics and phenotypes Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APC) of the human immune system. DCs are constantly scanning their environment for intruding pathogens or tissue damage. The ingested and processed antigens are presented to T cells, both under inflammatory and non-inflammatory conditions. Therefore, DCs are gatekeepers of immunity Read More

Background Tolerance is induced and maintained both centrally and peripherally, each with a non-redundant function in maintaining receptor diversity while curtailing self-reactivity It was observed more than 50 years ago that non-identical twin calves sharing a placenta do not react to each other’s erythrocytes, and it was hypothesised that in utero exposure rendered them tolerant Read More

24th July 2018

This study demonstrated the interplay between viral replicative, immunological and epidemiological

Background Tolerance is induced and maintained both centrally and peripherally, each with a non-redundant function in maintaining receptor diversity while curtailing self-reactivity It was observed more than 50 years ago that non-identical twin calves sharing a placenta do not react to each other’s erythrocytes, and it was hypothesised that in utero exposure rendered them tolerant Read More

Dendritic cells characteristics and phenotypes Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APC) of the human immune system. DCs are constantly scanning their environment for intruding pathogens or tissue damage. The uptaken and processed antigens are presented to T cells, both under inflammatory and non-inflammatory conditions. Therefore, DCs are gatekeepers of immunity Read More

Dendritic cells characteristics and phenotypes Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APC) of the human immune system. DCs are constantly scanning their environment for intruding pathogens or tissue damage. The uptaken and processed antigens are presented to T cells, both under inflammatory and non-inflammatory conditions. Therefore, DCs are gatekeepers of immunity Read More