The Natural Selection Theory

“A theory of antibody formation is proposed which postulates the spontaneous presence, in the blood of an animal, of small numbers of antibody molecules against all antigens to which the animal can respond, and delegates to the antigen the sole role of carrying such specific globulin molecules from the circulation into cells in which these molecules can induce the production of more of their kind”.

Nobel Prize 1984

Jerne, N.K, Proc Nat Acad Sci USA 41:849, 1955