The Instruction Theories

“The antigen acted as a template which instructed the cell what antibody it has to form”

Breinl, F. & Haurowitz, F.,  Z. Physiol. Chem., 192:45, 1930.

“The completed antibody molecule will therefore possess to some degree a stereochemical correspondence with the antigen for the reason that each structural unit has been selected and oriented, at the moment of synthesis into the antibody molecule, to fit the local configuration and affinities of the antigen surface”

Mudd, S., J. Immunol. 23:423-427, 1932