T cell Receptor

Tak Mak and colleagues using differential screening (Yanagi et al., Nature 308: 145-149) and Mark Davis and colleagues using cDNA substractive hybridization (Hedrick et al., Nature 308: 149-153, 1984; Hedrick et al., Nature 308: 153-158, 1984), independently were able to clone the genes of the T cell Receptor (TCR), elucidate its basic structure, and demonstrate that the TCR genes, like the Ig genes, rearrange at the DNA level to generate the repertoire diversity.

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University