T cell Receptor

Tak Mak and colleagues using differential screening (Yanagi et al., Nature 308: 145-149) and Mark Davis and colleagues using cDNA substractive hybridization (Hedrick et al., Nature 308: 149-153, 1984; Hedrick et al., Nature 308: 153-158, 1984), independently were able to clone the genes of the T cell Receptor (TCR), elucidate its basic structure, and demonstrate that the TCR genes, like the Ig genes, rearrange at the DNA level to generate the repertoire diversity.