Monoclonal Clonotypic Antibodies

Reinherz and his colleagues (J Exp Med 157:705-719, 1983) using human T cell clones, and Marrack and colleagues (J Exp Med 157: 1149-1169, 1983) using mouse T cell hybridomas obtained monoclonal clonotypic antibodies that identified on the T cell membrane a heterodimer of 90KD associated with the T3 molecule (now CD3).