MHC Restriction

In 1974, Peter Doherty and Rolf Zinkernagel published a series of papers (Nature 248:701, 1974; Nature 251: 547, 1974) demonstrating that recognition of viral infected target cells by CD8+ T cells is restricted by MHC class I genes. They put forward the concept of ‘MHC restriction’.

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University