Lymphocyte Differentiation


F. A P. Miller in a series of classical experiments demonstrated that neonatally thymectomized mice are lymphopenic and immunodeficient and proposed that the thymus is the lymphoid organ where small immunocompetent lymphocytes are differentiated.

Miller, Lancet 278:748-749, 1961; Miller, Nature 195: 138-1319, 1962; Miller, Proc Roy Soc London B 16:415-428, 1962