In 1991, a proteasome gene was found in the HLA class II region (Glynne et al, Nature 353:357, 1991). Soon after, Rock et al (Cell 78:761, 1994) demonstrated that the low molecular weight proteasome (LMP) was involved in the generation of peptides that are then transported into the ER by TAP.

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University