Linked Ir Genes

Allan Rosenthal and Ethan Shevach (J Exp Med 136: 1207, 1972; J Exp Med 138: 1194 and 1213, 1973) demonstrated that antigen recognition by guinea pig T cells was regulated by macrophages and restricted by the MHC class II linked Ir genes.

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University