Discovery of the MHC

During the first decade of the 20th century, two important advances were made that paved the way to the discovery of the MHC in later years:

  1. Loeb and Tyzzer discovered that the resistance and susceptibility to transplantable tumors are genetically determined by at least 15 genes.
  2. Inbred strains of mice were developed by Little (DBA/1, DBA/2, C57BL), Bagg (BALB/c) and Strong (CBA and C3H) that facilitated the understanding of transplant biology.

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University