Direct Allorecognition

In 1991 Rotzschke et al (J Exp Med 174:1059, 1991) demonstrated that cytotoxic T lymphocytes could directly recognize allogeneic MHC-peptide complexes, without presentation by autologous antigen presenting cells. This phenomenon is known as direct allorecognition.

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University