Clonal selection theory

F. MacFarlane Burnet proposed in his “Clonal selection theory” that antigens are recognized by immunocompetent cells that either clonally expand to mount an immune response or are deleted resulting in tolerance. However, the identity of the immunocompetent cells was still unknown

Burnet, Austr J Sci 20:67-69, 1957

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University