C4 component of complement

In 1963, Shrefler and Owen (Genetics 48:9, 1053) discovered a mouse serum protein whose levels were genetically determined by genes located on the H-2 loci. They called it ´Ss´, later identified as the C4 component of complement.

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University