Bare Lymphocyte Syndrome

In 1993, Steimie et al (Cell 75:135, 1993) demonstrated that the ‘Bare Lymphocyte Syndrome’, characterized by the complete lack of HLA class II expression leading to severe combined immunodeficiency, is caused by deletion in a gene that regulates the expression of class II molecules, the Class II Transactivator (CIITA).

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University