immune reconstitution inflammatory syndrome (IRIS)

IRIS occurs in a proportion of patients with HIV infection who are also receiving highly active antiretroviral therapy (HAART). They exhibit a deterioration in their clinical status, despite control of virologic and immunologic parameters, as evidenced by decreasing viral load and rising CD4 count. This clinical response results from the interaction between an improving immune system and organisms that colonised the body during earlier stages of HIV infection.

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International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University