Graphical abstract demonstrating the antimicrobial activity of IL-26 against intracullar bacteria like M.leprae: IL-26 is able to colocalize with M.leprae in infected human monocyte-derived-macrophages. IL-26 may also promotes intracellular killing by promoting phagolysosomal fusion. By binding to the DNA of dead cells, IL-26 allows the cytoplasmic DNA receptor STING to bring about autophagy. (Source: Dan et al., JCI 2019)

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University