Search Results:

Tumour Microenvironment

Tumours are organ-like structures composed of different cell types whose interactions are required to promote their maintenance, growth and metastasis. Increasing evidence indicates that the tumour microenvironment (TME) can dictate aberrant cellular function and play a critical role in the subsequent development of more advanced and refractory malignancies. TME is constituted of cancer-associated fibroblast (CAFs), Read More

Tumour Microenvironment

Tumours are organ-like structures composed of different cell types whose interactions are required to promote their maintenance, growth and metastasis. Increasing evidence indicates that the tumour microenvironment (TME) can dictate aberrant cellular function and play a critical role in the subsequent development of more advanced and refractory malignancies. TME is constituted of cancer-associated fibroblast (CAFs), Read More

Cancer Immunotherapy with γδ T cells

General introduction on antigen recognition by γδ T cells Each γδT cell produces a unique ‘clonal’ γδTCR (via somatic recombination) that assembles with CD3 proteins on the cell surface of γδT cells to transduce activating signals into the cell. This process and the nature of the receptors resembles the formation and structure of the antibodies. Read More

MDSC Promote Tumor Growth and Escape

What are MDSCs? Myeloid-derived suppressor cells (MDSCs) are a group of myeloid cells with potent immunoregulatory activity. Two major MDSC subsets have been identified in humans: granulocytic or polymorphonuclear MDSCs (PMN-MDSCs) and monocytic MDSCs (M-MDSCs): PMN-MDSCs are phenotypically and morphologically similar to neutrophils. They are defined as CD11b+CD14–CD15+ (or CD66b+)CD33+. M-MDSCs are similar to monocytes. Read More

Strategies to apply gamma/delta T cells for Immunotherapy

Activation of γδ T cells γδ T cells exhibit preferential pairing of variable region genes (Vγ and Vδ genes) in the TCR. For example, in the peripheral blood of adults, most γδ T cells usually express Vδ2 paired with Vγ9 [2]. γδ T cells expressing Vδ1, Vδ3, or Vδ5 together with one of the remaining Read More

Immunity to Viral Infections

Introduction Viruses are infectious agents, replicating inside of living cells. The viral replication cycle in an infected cell follows a typical routine: Attachment and entry: The virus attaches to the host cell membrane via specific receptors and enters the host cell, delivering its genetic material into the cell. Replication and Assembly: The virus takes over Read More

Immune Responses to Cancer

The immune response to cancer is best viewed as a specialized case of immunity in which the malignant cell has adapted and learned how to persist. The immunological surveillance theory was originally put forth independently by Burnet and Thomas, who suggested that the immune system continually surveyed the body for the presence of malignant cells, Read More

Cytokines as biomarkers for HCV

Liver and blood cytokine microenvironment in HCV patients The outcome of HCV infection depends on the interplay of many factors, such as the genotype and genetic variability of HCV virus, as well as the host’s genetic background and efficacy of immune responses, among others. During acute HCV infection, the presence of virus recruits multiple mechanisms Read More

Immune Responses to Cancer

The immune response to cancer is best viewed as a specialised case of immunity in which the malignant cell has adapted and learned how to persist. The immunological surveillance theory was originally put forth independently by Burnet and Thomas, who suggested that the immune system continually surveyed the body for the presence of malignant cells, Read More

Immune Responses to Cancer

The immune response to cancer is best viewed as a specialised case of immunity in which the malignant cell has adapted and learned how to persist. The immunological surveillance theory was originally put forth independently by Burnet and Thomas, who suggested that the immune system continually surveyed the body for the presence of malignant cells, Read More

 
 
 
 
 
 
International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineScience Education PrizesElizabeth Glazer Pediatric Aids FoundationAlere