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Novel Therapeutic strategies for Autoimmune Diseases

The human immune system is a complex network of specialised cells and organs that protects the body from infections. At the core of the immune system is the ability to recognise the difference between self and non-self. Autoimmune diseases arise from an overactive and misguided immune response of the body against substances and tissues normally Read More

My eyes cross at twilight

A 25 years-old, teacher, complains of double vision. She finds it difficult to talk after prolonged speaking. She is pregnant.Episodes of double vision began 6 weeks ago. Elsa’s husband reported fluctuating droopy eyelids in the morning…


Definition Hematopoiesis is the generation of new blood cells from multipotent hematopoietic stem cells (HSCs) 1.   HSCs origins & hematopoietic compartments In the embryo, HSCs arise from mesoderm 1. Hemangioblasts from the yolk sac & pre-aortic region1 migrate first to the foetal liver and spleen, and eventually also to the bone marrow2. HSCs persistin Read More

A case of decreased joint function, fever and rash

A 7 year old girl presented to her local hospital for the second time in 3 months with arthralgia, a migratory skin rash and fever for 5 days. She was admitted and within 2 days…

A case of scaly annular plaques

A 45 year old male is referred from outpatient clinic to a hospital dermatology department with well dermacated erythematous scaly annular plaques scattered on his…

Case of eye injury and decreased vision

A 12 year old boy is brought into the paediatric casualty by his parents approximately 18 hours after sustaining a penetrating knife injury to his left eye. The child was…

A 7 year old with severe muscle weakness and difficulty walking

A 7 year old female presents with a three week history of painful elbows, wrists and hands, generalised weakness and difficulty walking. History: Painful elbows, wrists and hands for 3/52; Sore throat; No early morning stiffness, but a generalised weakness …

14 year old with severe hip pain

A 14 and half year old boy presents with a recent history of tender temperomandibular joints and regular morning stiffness in both hips. He has a limited range of movement in his hips, especially abduction and adduction, and is no longer able to run and play games with his brothers.

Treating rhematoid arthritis with peptide-specific CD8+ regulatory T cells

The autoimmune disorder rheumatoid arthritis (RA) is characterized by joint inflammatio…

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineScience Education PrizesElizabeth Glazer Pediatric Aids FoundationAlere