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Tuberculosis Protracted or chronic bacterial infections are often caused by organisms that have an intracellular phase; this requires that they are adept at the penetration, evasion, and exploitation of the host immune response. The classic example of a chronic bacterial infection is seen with Mycobacterium tuberculosis, the causative organism of tuberculosis (TB), a major public health Read More

The immune system evolves multiple mechanisms for controlling self-reactivity, and defects in one or more of these mechanisms can lead to breakdown of central or peripheral tolerance. Under certain circumstances this system can be misdirected towards self antigens Accordingly, aberrant responses against self are implicated in >80 inflammatory disorders, collectively defined as autoimmune diseases. Among Read More

Tuberculosis Protracted or chronic bacterial infections are often caused by organisms that have an intracellular phase; this requires that they are adept at the penetration, evasion, and exploitation of the host immune response. The classic example of a chronic bacterial infection is seen with Mycobacterium tuberculosis, the causative organism of tuberculosis (TB), a major public health Read More

Immuno-Algeria Student Presentations   Student Presentations – Week 2 Lorraine Tsitsi Pfavayi – Characterising serological reactivity to fungal antigens in Zimbabwean children Arezki Samer – Ameliorative effect of probiotic supernatant on indomethacin-induced small intestinal injury in mouse models of inflammatory bowel diseases: The experimental enteropathy. Khaoula Attia – Hyper IgE Syndrome: Clinical and biological features Read More

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Protracted or chronic bacterial infections are often caused by organisms that have an intracellular phase; this requires that they are adept at the penetration, evasion, and exploitation of the host immune response. The classic example of a chronic bacterial infection is seen with Mycobacterium tuberculosis (M.tb), the causative organism of tuberculosis. These bacteria invade the Read More

The human immune system is a complex network of specialised cells and organs that protects the body from infections. At the core of the immune system is the ability to recognise the difference between self and non-self. Autoimmune diseases arise from an overactive and misguided immune response of the body against substances and tissues normally Read More

Protracted or chronic bacterial infections are often caused by organisms that have an intracellular phase; this requires that they are adept at the penetration, evasion, and exploitation of the host immune response. The classic example of a chronic bacterial infection is seen with Mycobacterium tuberculosis, the causative organism of tuberculosis. These bacteria invade the host Read More

Immune Evasion Strategies by Pathogens There are various strategies that pathogens use to evade the host immune response. The following are some of the mechanisms pathogens use: Hiding away by invading immune privileged tissue eg. CNS Making themselves “invincible” by shielding surface proteins eg. glycan shield in HIV Blocking recognition by producing decoy MHC molecules that Read More

Introduction to Immune Deficiency Disorders The immune deficiency conditions are a group of disorders that result from one or more abnormalities of the immune system and that manifest clinically as an increased susceptibility to infection. This group of human diseases was ushered in by a single seminal observation made by a clinician who carefully studied Read More