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Metabolism of Dendritic Cells Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) of the immune system and constitute a bridge between innate and adaptive immunity. DCs comprise a highly heterogeneous cell population able to receive and interpret signals either from invading pathogens or dying cells, and to respond to them through the Read More

Dendritic cells characteristics and phenotypes Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APC) of the human immune system. DCs are constantly scanning their environment for intruding pathogens or tissue damage. The ingested and processed antigens are presented to T cells, both under inflammatory and non-inflammatory conditions. Therefore, DCs are gatekeepers of immunity Read More

Background Tolerance is induced and maintained both centrally and peripherally, each with a non-redundant function in maintaining receptor diversity while curtailing self-reactivity It was observed more than 50 years ago that non-identical twin calves sharing a placenta do not react to each other’s erythrocytes, and it was hypothesised that in utero exposure rendered them tolerant Read More

Background Tolerance is induced and maintained both centrally and peripherally, each with a non-redundant function in maintaining receptor diversity while curtailing self-reactivity It was observed more than 50 years ago that non-identical twin calves sharing a placenta do not react to each other’s erythrocytes, and it was hypothesised that in utero exposure rendered them tolerant Read More

Dendritic cells characteristics and phenotypes Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APC) of the human immune system. DCs are constantly scanning their environment for intruding pathogens or tissue damage. The uptaken and processed antigens are presented to T cells, both under inflammatory and non-inflammatory conditions. Therefore, DCs are gatekeepers of immunity Read More

Dendritic cells characteristics and phenotypes Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APC) of the human immune system. DCs are constantly scanning their environment for intruding pathogens or tissue damage. The uptaken and processed antigens are presented to T cells, both under inflammatory and non-inflammatory conditions. Therefore, DCs are gatekeepers of immunity Read More

A 55-year old HIV-infected male was referred to the Dermatology Outpatient Clinic with a four month history of a swollen face and multiple skin nodules. Three years prior to this presentation, the patient was treated at his local clinic for a persistent rash.