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My hands swell and are painful

Eva is a 50-year-old Caucasian woman who presents to the clinic with complaints of hand and feet swelling to the point of visible deformities. Her joint pain wakes her up several times during the night and she has morning stiffness for several hours.

Metabolic Adaptation to Pathologic Milieu

METABOLISM: A GUIDING FORCE FOR IMMMUNITY Metabolism in simple terms refers to the cellular reactions that lead to energy generation from food such as breaking down proteins into amino acids, carbohydrates into simple sugars such as glucose, fats into fatty acids, etc. It is organised into different metabolic pathways to maximise the capture of energy Read More

How metabolic rewiring influences macrophage function

06 July 2023

Recently, a group from the Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, studied how macrophage fumarate hydratase restrains mtRNA-mediated interferon production…

Keep up while the storm is raging

Norberto, a 23-year old white male in his third relapse of a B cell acute lymphoblastic leukemia (B-ALL) has been treated with an infusion of autologous CD19 Chimeric Antigen Receptor (CAR) T cells (CAR-T cells). Ten days later, he felt severe discomfort in the middle of the night…

Immuno-Jaipur Highlight: Part 2 of Day 3

15th November

In addition to talks by Prof Abbas, Day 3 of Immuno-Jaipur included talks on autoimmunity and chronic inflammation. Prof. Bernhard Fleisher gave a talk on autoimmunity in the central nervous system where he discussed various autoimmune diseases such as Myasthenia Gravis, Encephalitis, Multiple sclerosis. Myasthenia gravis is an autoimmune disease…

Fireworks of autoimmunity from birth

A five-month-old male infant was brought into the emergency department by parents with hypotonicity (reduced muscular tone) and drowsiness that began the evening before. The infant presented with refractory atopic dermatitis and recent weight loss.

I have spots and my skin burns

Peter, a 60 year-old Caucasian policeman, complains of a painful burning sensation in his lower extremities lasting for several months. Lower limbs petechiae (small purple/red hemorrhagic spots) appeared one week ago.

A case of decreased joint function, fever and rash

A 7 year old girl presented to her local hospital for the second time in 3 months with arthralgia, a migratory skin rash and fever for 5 days. She was admitted and within 2 days…

A case of acute fever, rash and vomiting

A 31 year old caucasian male presented to the HIV clinic complaining of recent onset of fever, vomiting, joint pain, muscle aches, sore throat and a fine red rash on his face and arms. All symptoms had worsened since they first started 2 days ago and seemed to be aggravated shortly…

International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineElizabeth Glazer Pediatric Aids FoundationStellenbosch University