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18 August 2021

Researchers from the University of Maryland and the US National Institutes of Health have discovered a novel pathway of host cell manipulation and innate immune evasion by Mtb. They have shown that the Mtb limits activation of a host cell defense complex, the inflammasome.

TGF-β is part of a large protein family comprising 33 members that are divided into subfamilies based on structural variations Effects of ligands of the TGF-β superfamily are mediated through serine threonine kinase receptors type I and type II, which act as heterodimers. Two co-receptors, endoglin (CD105) and betaglycan alter the response to various ligands Read More

T lymphocytes (named “T” after their maturation in the thymus) are one of the two major populations of the adaptive immune system and primary initiators, coordinators, and regulators of the adaptive immune response. T lymphocytes comprise approximately 30 percent of white blood cells in human peripheral blood. However, peripheral blood T cells account for only Read More

3rd July, 2017

The role of the mechanistic target of rapamycin (mTOR pathway) in asthma was not well understood although it is known to have effects on immune responses. Scientists from…

T lymphocytes (named “T” after their maturation in the thymus) are one of the two major populations of the adaptive immune system and primary initiators, coordinators, and regulators of the adaptive immune response. T lymphocytes comprise approximately 30 percent of white blood cells in human peripheral blood. However, peripheral blood T cells account for only Read More

A 31 year old caucasian male presented to the HIV clinic complaining of recent onset of fever, vomiting, joint pain, muscle aches, sore throat and a fine red rash on his face and arms. All symptoms had worsened since they first started 2 days ago and seemed to be aggravated shortly…