Resistance


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Resistance

Introduction

HIV infects CD4 bearing cells

Once you have read this section you will become familiar with how drug resistance mutations are introduced. With the aid of our unique colour graphics you will gain a clear understanding of the general principles of mutations and how they confer resistance on the different classes of drugs.

Reverse Transcriptase (RT) Mutations

HIV infects CD4 bearing cellsIn this section you will be able to download an interactive PDF that describes how drug resistance mutations are introduced into the HIV reverse transcriptase enzyme.  The graphic depicts the general principle of RT mutations that would confer resistance to both NRTI and NNRTI classes of antiretroviral drugs.

Protease (PR) Mutations

In this section you will be able to download an interactive PDF that describes how drug resistance mutations are introduced into the HIV protease enzyme.  The graphic depicts the general principle of PR mutations that would confer resistance to the protease inhibitor class of antiretroviral drugs.

Envelope gp41 Mutation

In this section you will be able to download an interactive PDF that describes how drug resistance mutations are introduced into the HIV envelope gp41 fusion protein. Mutations in gp41 will confer resistance to the entry inhibitor enfuvirtide (T-20 or fuzeon) antiretroviral drugs.

Download RT Mutation Guide

Protease (PR) Mutations

In this section you will be able to download an interactive PDF that describes how drug resistance mutations are introduced into the HIV protease enzyme.  The graphic depicts the general principle of PR mutations that would confer resistance to the protease inhibitor class of antiretroviral drugs.

Download PR Mutation Guide

Envelope gp41 Mutation

HIV infects CD4 bearing cellsIn this section you will be able to download an interactive PDF that describes how drug resistance mutations are introduced into the HIV envelope gp41 fusion protein. Mutations in gp41 will confer resistance to the entry inhibitor enfuvirtide (T-20 or fuzeon) antiretroviral drugs.

 

 

 

Download Envelope gp41 Mutation Guide

 
 
 
 
 
 
International Union of Immunological SocietiesUniversity of South AfricaInstitute of Infectious Disease and Molecular MedicineScience Education PrizesElizabeth Glazer Pediatric Aids FoundationAlere