Malaria causes between 300 million and 500 million clinical episodes worldwide and 0.5 million to 3 million deaths annually, disproportionally affecting immune naïve children under the age of 5 years living in sub-Saharan Africa.¹ Malaria has evolved unique strategies to evade the host immune system and therefore be able to cause repeated and serious infections. The understanding of host immune responses to malaria and the immune evasion techniques malaria employs is vital to the development of an efficacious and safe vaccine which could prevent incredible morbidity and millions of deaths annually.