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Mitochondrial respiratory capacity Is a critical regulator of CD8+ T Cell memory development
The life of a T cell can be very demanding—at least as far as metabolism is concerned.[more]
Loss of anti-viral immunity by infection with a virus encoding a cross-reactive pathogenic epitope
The purpose of vaccination against viruses is to induce strong neutralizing antibody responses that inactivate viruses on contact, and strong T cell responses that attack and kill virus-infected cells.[more]
The risk of AIDS-defining events is decreasing over time in German HIV-1 seroconverter cohort
Shortly after the introduction of HAART in 1996, studies showed a protective effect of HAART on time to acquired immunodeficiency syndrome (AIDS).[more]
CD8+ T-cells expressing interferon gamma or perforin play antagonistic roles in heart injury in experimental Trypanosoma cruzi cardiomyopathy
In Chagas disease, CD8+ T-cells are critical for the control of Trypanosoma cruzi during acute infection. Conversely, CD8+ T-cell accumulation in the myocardium during chronic infection may be the cause of the tissue injury leading to chronic chagasic cardiomyopathy (CCC).[more]
Systematic Review of Mucosal Immunity Induced by Oral and Inactivated Poliovirus Vaccines against Virus Shedding following Oral Poliovirus Challenge
Inactivated poliovirus vaccine (IPV) may be used in mass vaccination campaigns during the final stages of polio eradication.[more]
T Regulatory cells control susceptibility to invasive pneumococcal pneumonia
Streptococcus pneumoniae is a major human bacterial pathogen causing a wide range of diseases.[more]
In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem Cells
HIV actively subverts the potent natural immune responses against it, particularly cellular cytotoxic T lymphocyte (CTL) responses.[more]
