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Polyfunctional type-1, -2, and -17 CD8+ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection
The cleavage of antigens by the enzyme caspase is associated with apoptosis which plays a prominent role in the generation of CD8+ T cell responses in various infectious diseases.[more]
Second-line antiretroviral therapy: long-term outcomes in South Africa.
An increasing proportion of people having started HIV therapy in resource-limited settings experience first-line treatment failure.[more]
Cellular Basis of Tissue Regeneration by Omentum
The wound healing properties of the human omentum are well known and have extensively been shown to promote tissue healing, revascularization and to control inflammation when surgically grafted to injured sites.[more]
A Highly Intensified ART Regimen Induces Long-Term Viral Suppression and Restriction of the Viral Reservoir in a Simian AIDS Model
An intensified multidrug ART regimen consisting of two reverse transcriptase inhibitors (emtricitabine and tenofovir), an integrase inhibitor (raltegravir), a boosted-protease inhibitor (ritonavir/darunavir) and a CCR5 blocker (maraviroc) [more]
Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response
Cell signaling for T-cell growth, differentiation, and apoptosis is initiated in the cholesterol-rich microdomains of the plasma membrane known as lipid rafts[more]
Primed T cell responses to chemokines are regulated by the immunoglobulin-like molecule CD31
CD31, or platelet endothelial cell adhesion molecule-1 (PECAM-1) is a member of the immunoglobulin gene superfamily expressed at high density at the lateral borders of endothelial cells and at a lower density on the surface of hematopoietic cells including T lymphocytes.[more]
Dendritic cell editing by activated Natural Killer Cells results in a more protective cancer-specific immune response
Natural Killer (NK) cells, which were originally identified as lymphoid cells capable of lysing a number of tumor cell lines in the absence of previous stimulation, are now appreciated as multifunctional innate immune cells.[more]
