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HIV-1 Vaccines and Adaptive Trial Designs
In the past 12 years, four large-scale efficacy trials of HIV vaccines have been conducted in various populations.[more]
Triple antiretroviral compared with zidovudine and single-dose nevirapine prophylaxis during pregnancy and breastfeeding for prevention of mother-to-child transmission of HIV-1 a randomised controlled trial
Breastfeeding is essential for child health and development in low-resource settings but carries a significant risk of transmission of HIV-1, especially in late stages of maternal disease[more]
Respiratory Syncytial Virus Interferon Antagonist NS1 Protein Suppresses and Skews the Human T Lymphocyte Response
Respiratory syncytial virus (RSV) is a leading cause of pediatric lower respiratory tract disease.[more]
Atazanavir associated with significant risk of kidney stones and renal impairment
Studies presented at last week’s BHIVA conference found that kidney stones were four times more common in people taking the protease inhibitor atazanavir than in people taking other drugs.[more]
Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure
Effective immunity to HIV is poorly understood. In particular, a role for antibody-dependent cellular cytotoxicity (ADCC) in controlling HIV is controversial.[more]
Family Health International (FHI) Statement on the FEM-PrEP HIV Prevention Study
Following a scheduled interim review of the FEM-PrEP study, a Family Health International pre exposure prophylaxsis (PrEP) study held in partnership with centers in Africa, the Independent Data Monitoring Committee (IDMC) has advised the study be closed.[more]
Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases
For HIV to enter T cells, the virus first binds to a primary surface receptor CD4 and then to a coreceptor, either CCR5 or CXCR4.[more]
