http://www.immunopaedia.org.za/ Breaking news from immunopaedia.org.za en http://www.immunopaedia.org.za/typo3conf/ext/tt_news/ext_icon.gif http://www.immunopaedia.org.za/ 18 16 Breaking news from immunopaedia.org.za TYPO3 - get.content.right http://blogs.law.harvard.edu/tech/rss Wed, 19 Jun 2013 08:25:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1523&cHash=83d6ec46ee5960c1854267bb97291f18 Viruses must enter cells before they can replicate, therefore they continuously evolve in order to... et al. the authors show how a small amount of mutations in transferrin receptor 1 can alter viral host specificity. Analysis of the ratio of synonymous to nonsynonymous DNA mutations in the rodent transferrin receptor identified a handful of residues that were under positive selection. These residues corresponded to the region of the receptor that interacts with the virus rather than those residues necessary for iron uptake. A search for human single-nucleotide polymorphisms identified transferrin receptor variants that reduced viral uptake in cultured human cells but maintained iron regulation. Demonstrating that in the constant arms race between viruses and the cells they infect, positive selection of residues involved in viral entry can be divorced from regions of the receptor that are essential for host function. Thus helping to expand our understanding of how viruses emerge from wildlife reservoirs, and how they drive the evolution of host genes. Link to article]]> Breaking News Wed, 19 Jun 2013 08:25:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1522&cHash=39084c527bb6c52ad3114c0cb9ab0754 Immunopaedia invites you to an immunology skills building workshop taking place this week. th South African AIDS conference, which runs from 18 - 21 June 2013 at the international conference centre (ICC) in Durban, South Africa. The conference provides an opportunity for participants to showcase the great work and contribution they are making in achieving our common goal of an HIV free world. If you are attending or planning to attend the conference please come and join members of the Immunopaedia team, Prof Clive Gray- chair and head of Immunology from the University of Cape Town and Shayne Loubser- PhD candidate from the AIDS Immunology Laboratory at the National Institute for Communicable Diseases in Johannesburg. The 90-minute workshop will explore the immunology of acute retroviral syndrome using materials from our award-winning online learning website. The workshop will present a clinical case study that then provides the platform for explaining the immunology of acute HIV infection, subsequent inflammation and the commencement of pathogenesis. The workshop is designed to be interactive and questions will be posed to stimulate discussions around this topic. Attendance can also earn you 2 CPD points. We look forward to meeting you. Click here to see the Conference Programme]]> Breaking News Tue, 18 Jun 2013 08:24:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1521&cHash=5f27214c133bfadb9f451d028772216d A new study provides the first evidence that pre-exposure prophylaxis (PrEP) can protect... Link to article]]> Breaking News Fri, 14 Jun 2013 10:01:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1520&cHash=4e15a35a404a6b1a9e6bf0db3026fc2a Neuroinflammation is known to play an important role in the pathogenesis of Parkinsons Disease... Link to article]]> Breaking News Thu, 13 Jun 2013 08:49:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1519&cHash=df515e326b1e5ec8ea9d0afe93c5b377 The US Food and Drug Administration (FDA) has approved the first four-strain influenza vaccine,... Link to article]]> Breaking News Wed, 12 Jun 2013 13:11:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1518&cHash=a1dfc79137f929807fcd76d29514458a Humoral immune responses to protein antigens are responsible for numerous unwanted medical... Link to article]]> Breaking News Tue, 11 Jun 2013 08:45:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1517&cHash=902147a26482b68d3c638205a3c0615e The interactions between closely aligned cells include a range of physiological processes such as... Link to article]]> Breaking News Mon, 10 Jun 2013 09:58:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1516&cHash=f67b4628ff6508756cbb1b2316414bdd Human cytomegalovirus (HCMV) is widespread and cannot be eliminated from the body Link to article]]> Breaking News Fri, 07 Jun 2013 08:51:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1515&cHash=6e754ef63ae857c00a97091e634ac71c With antiretroviral therapy (ART) becoming more successful, outcomes in patients with HIV have... + cell count between 350 and 499cells/ul while no increase in mortality was seen with CD4⁺ cell counts greater than 500cells/ul. Thereby concluding that if administered early enough in the treatment of HIV, modern ART Is able to reduce mortality risk to that of a normal life expectancy Link to article]]> Breaking News Thu, 06 Jun 2013 08:54:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1514&cHash=69cd7a28756d1ba0afd121bb8fe38824 CD8 T cells play a key role in eliminating intracellular infections and tumors. Link to article]]> Breaking News Wed, 05 Jun 2013 09:41:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1513&cHash=547c929323f9e295b09e6bf1ddb898b7 A recent publication in the Journal of the American Chemical society demonstrates a novel method... Link to article]]> Breaking News Tue, 04 Jun 2013 10:42:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1512&cHash=191a1e39485976187b9728e2aeb47acb A team led by researchers from the University of Pittsburgh School of Medicine has for the first... Link to article]]> Breaking News Mon, 03 Jun 2013 09:10:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1511&cHash=d7f21420a0b209577a8a64969904f9bd Stimulation of antigen-presenting cells by Toll like receptor 9 (TLR9) agonists enhances the uptake... Link to article]]> Breaking News Fri, 31 May 2013 11:36:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1510&cHash=6af31c073ce694d12360e9e15ac6d8f3 Chronic ongoing infection of basal keratinocytes with high-risk human papillomavirus (hrHPV) may... Link to article]]> Breaking News Thu, 30 May 2013 09:33:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1509&cHash=ef202f92f6718b896f71153605b772f4 Multicellular organisms fight bacterial and fungal infections by producing peptide-derived... Link to article]]> Breaking News Wed, 29 May 2013 08:43:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1508&cHash=be270ff0e4bc73e7668233c60be2066d According to the WHO guidelines for first-line antiretroviral therapy (ART) in resource-limited... Link to article]]> Breaking News Tue, 28 May 2013 09:01:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1507&cHash=1e481be69971112acd795ae7fb6be39f Cochlin is an extracellular matrix protein produced by follicular dendritic cells (FDCs). -/- mice showed reduced survival linked to defects in local cytokine production, recruitment of immune effector cells, and bacterial clearance. Thus demonstrating an unexpected function of FDC in modulating innate immunity and a role for secondary lymphoid organ and particularly local lymph nodes in the amplification of the innate immune response by the release of modulators such as cochlin. Link to article]]> Breaking News Mon, 27 May 2013 09:53:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1506&cHash=5e06c60e144d321efff4250bf0f54172 T cells bearing autoreactive T cell antigen receptors are typically eliminated via thymocyte... in vivo, and the relationship between thymocyte death and phagocytic clearance, are unknown. This study therefore examined a synchronized population of developing thymocyte undergoing negative selection within three-dimensional living thymic tissue. However in spite of this synchronized early response, individual thymocytes then undergo a delayed and asynchronous entry into apoptosis somewhere between 2 and 12 hours later. Using time-lapse two-photon imaging, the study then showed that thymocyte death and the clearance of the dead cells actually occurs at the same time, with thymocytes already engulfed by a macrophage before the cell death-related changes in chromatin and membrane permeability are evident. Thus providing a timeline of the major events during negative selection, and suggesting close coupling between thymocyte death and clearance by macrophages. Link to article]]> Breaking News Fri, 24 May 2013 08:42:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1505&cHash=6dd7d7b547779b4a0a9c55515b27c549 This week drug makers Sanofi and Regeneron announced results from their Phase 2a study of the... Link to article]]> Breaking News Thu, 23 May 2013 09:01:00 +0200 http://www.immunopaedia.org.za/index.php?id=235&L=0%20and%201%3D1--&tx_ttnews%5Btt_news%5D=1504&cHash=058b13d9a22e1bbed88f1443d0beb74a Understanding vaccine-mediated correlates of immunity is critical for the design of novel... Link to article]]> Breaking News Wed, 22 May 2013 08:53:00 +0200